Functional FCGR2B gene variants influence intravenous immunoglobulin response in patients with Kawasaki disease

J Allergy Clin Immunol. 2011 Sep;128(3):677-80. doi: 10.1016/j.jaci.2011.04.027. Epub 2011 May 20.

Abstract

In Kawasaki Disease patients, the authors show associations between high-dose intravenous immunoglobulin (IVIG) response and a polymorphism in the FCγRIIB. This provides basis for defining the IVIG regulatory mechanisms and pharmacogenomic approach to IVIG therapy.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Child
  • Child, Preschool
  • Female
  • Gene Frequency
  • Genetic Variation*
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage
  • Immunoglobulins, Intravenous / therapeutic use*
  • Infant
  • Male
  • Mice
  • Mucocutaneous Lymph Node Syndrome / genetics*
  • Mucocutaneous Lymph Node Syndrome / immunology
  • Mucocutaneous Lymph Node Syndrome / therapy*
  • Polymorphism, Genetic
  • Receptors, IgG / genetics*
  • Receptors, IgG / metabolism
  • Treatment Outcome

Substances

  • FCGR2B protein, human
  • Immunoglobulins, Intravenous
  • Receptors, IgG