[Prognostic value of lipopolysaccharide and lipopolysaccharide-binding protein serum levels in cancer patients with sepsis]

Zh Mikrobiol Epidemiol Immunobiol. 2011 Mar-Apr:(2):82-4.
[Article in Russian]

Abstract

Aim: Analysis of LPS and LPS-binding protein (LBP) serum levels and prognostic value evaluation in cancer patients with sepsis.

Materials and methods: Blood samples of 17 healthy donors and 46 cancer patients with sepsis were analyzed by using "Hycult biotechnology" kits (The Netherlands).

Results: Serum LPS level in cancer patients with sepsis was increased significantly. A substantial decrease of LBP level was detected in blood samples of deceased patients.

Conclusion: Dynamic increase of LPS serum level and decrease of LPS-binding protein serum level in cancer patients should be considered as an unfavorable factor for sepsis.

Publication types

  • English Abstract

MeSH terms

  • Acute-Phase Proteins*
  • Biomarkers / blood
  • Carrier Proteins* / blood
  • Case-Control Studies
  • Humans
  • Lipopolysaccharides / blood*
  • Membrane Glycoproteins* / blood
  • Neoplasms / blood*
  • Neoplasms / complications
  • Neoplasms / mortality
  • Neoplasms / physiopathology
  • Prognosis
  • Risk Factors
  • Sepsis / blood*
  • Sepsis / complications
  • Sepsis / mortality
  • Sepsis / physiopathology
  • Survival Rate

Substances

  • Acute-Phase Proteins
  • Biomarkers
  • Carrier Proteins
  • Lipopolysaccharides
  • Membrane Glycoproteins
  • lipopolysaccharide-binding protein