Abstract
The ¹⁷⁷Lu-[tris(1,10-phenanthroline)lutetium(III)] complex (¹⁷⁷Lu-PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 × 10¹³ n.cm⁻².s⁻¹) of natural Lu₂(NO₃)₃ sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the (177)Lu-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild-type male rats and bio-distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.
MeSH terms
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Animals
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Coordination Complexes / administration & dosage
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Coordination Complexes / chemistry*
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Coordination Complexes / pharmacokinetics
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Coordination Complexes / therapeutic use*
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Humans
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Injections, Intravenous
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Male
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Organometallic Compounds / administration & dosage
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Organometallic Compounds / chemistry*
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Organometallic Compounds / pharmacokinetics
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Organometallic Compounds / therapeutic use*
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Phenanthrolines / administration & dosage
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Phenanthrolines / chemistry*
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Phenanthrolines / pharmacokinetics
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Phenanthrolines / therapeutic use*
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Quality Control
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Radiochemistry / methods*
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Radiochemistry / standards
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Rats
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Solutions
Substances
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Coordination Complexes
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Organometallic Compounds
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Phenanthrolines
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Solutions
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tris(1,10-phenanthroline)lutetium(III)