CFTR three-dimensional structure

Methods Mol Biol. 2011:741:329-46. doi: 10.1007/978-1-61779-117-8_22.

Abstract

CFTR is a member of the ATP-binding cassette family of membrane proteins. This is one of the best characterised membrane protein families in terms of structure and function. CFTR operates as an ion channel, unlike nearly all other family members which are active transporters. Here, we discuss methods that have allowed such data to be obtained for CFTR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cryoelectron Microscopy
  • Crystallography, X-Ray
  • Cystic Fibrosis Transmembrane Conductance Regulator / chemistry*
  • Detergents / chemistry
  • Humans
  • Imaging, Three-Dimensional
  • Microscopy, Electron, Transmission
  • Protein Structure, Tertiary
  • Solubility

Substances

  • Detergents
  • Cystic Fibrosis Transmembrane Conductance Regulator