p-hydroxyacetophenone amides from Cystobacter ferrugineus, strain Cb G35

Wiebke Zander; Kathrin I Mohr; Klaus Gerth; Rolf Jansen; Rolf Müller

doi:10.1021/np1006789

p-hydroxyacetophenone amides from Cystobacter ferrugineus, strain Cb G35

J Nat Prod. 2011 Jun 24;74(6):1358-63. doi: 10.1021/np1006789. Epub 2011 May 19.

Authors

Wiebke Zander¹, Kathrin I Mohr, Klaus Gerth, Rolf Jansen, Rolf Müller

Affiliation

¹ Research Group Microbial Drugs, Helmholtz Centre for Infection Research , Inhoffenstrasse 7, 38124 Braunschweig, Germany.

PMID: 21591808
DOI: 10.1021/np1006789

Abstract

A family of six novel p-hydroxyacetophenone amides, 1-6, was isolated from Cystobacter ferrugineus, strain Cb G35. Their structures were elucidated by ESI-TOF mass spectrometry and NMR spectroscopy. Feeding experiments with labeled [¹³C₉,¹⁵N]-tyrosine and [d₁₀]-leucine identified the biosynthetic precursors of 1.

MeSH terms

Acetophenones / chemistry
Acetophenones / isolation & purification*
Amides / chemistry
Amides / isolation & purification*
Humans
Leucine / chemistry
Microbial Sensitivity Tests
Molecular Structure
Myxococcales / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Spectrometry, Mass, Electrospray Ionization
Tyrosine / chemistry

Substances

Acetophenones
Amides
Tyrosine
4-hydroxyacetophenone
Leucine