Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite

Tomohiro Doura; Hiroshi Nonaka; Shinsuke Sando

doi:10.1039/c1cc12044a

Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite

Chem Commun (Camb). 2012 Feb 1;48(10):1565-7. doi: 10.1039/c1cc12044a. Epub 2011 May 17.

Authors

Tomohiro Doura¹, Hiroshi Nonaka, Shinsuke Sando

Affiliation

¹ INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan.

PMID: 21584328
DOI: 10.1039/c1cc12044a

Abstract

The first dual activatable hypochlorite ((-)OCl)-sensing probe was developed, based on a new proof-of-concept design involving signal-activatable (1)H chemical probes using the triple-resonance NMR technique. The probe enabled fluorescence-(1)H MR dual turn-on detection of (-)OCl in solution and in crude tissue extracts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coumarins / chemical synthesis
Coumarins / chemistry*
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
Hypochlorous Acid / analysis*
Magnetic Resonance Spectroscopy
Molecular Structure
Protons

Substances

Coumarins
Fluorescent Dyes
Protons
Hypochlorous Acid
3,4-dihydrocoumarin