Abstract
The uncoupling protein found in mitochondria from thermogenic brown adipose tissue is structurally very similar to two other mitochondrial carrier proteins transporting ADP/ATP and phosphate, respectively. Similarities are also seen with the mechanism of these carriers, which are part of a family of H+/OH(-)-substrate anion co-transporters, further strengthening the evidence that the uncoupling protein has evolved from this family of mitochondrial carrier proteins.
MeSH terms
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Adipose Tissue, Brown / metabolism*
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Amino Acid Sequence
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Animals
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Biological Evolution*
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Carrier Proteins / classification
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Hydroxides
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Ion Channels
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Membrane Proteins / classification
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism
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Mitochondrial Proteins
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Molecular Sequence Data
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Protein Conformation
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Protons
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Uncoupling Protein 1
Substances
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Carrier Proteins
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Hydroxides
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Ion Channels
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Membrane Proteins
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Mitochondrial Proteins
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Protons
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Uncoupling Protein 1
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hydroxide ion