The title compound, C(26)H(26)N(2)O(2)S, was prepared by the reaction of thio-phene-2,5-dicarboxylic acid and 2-amino-4-tert-butyl-phenol. One of the tert-butyl groups is disordered over two conformations, with occupancies of 0.539 (1) and 0.461 (2). The two 1,3-benzoxazole rings are almost planar, with dihedral angles of 0.83 (18) and 1.64 (17)° between the five- and six-membered rings. The thio-phene ring makes dihedral angles of 21.54 (19) and 4.49 (18)° with the planes of the five-membered oxazole rings. The crystal packing is controlled by π-π stacking inter-actions involving the thio-phene and benzene rings, with a centroid-centroid distance of 3.748 (2) Å.