In the title compound, C(6)H(16)N(4)O(4)·4H(2)O, the tetra-zinane mol-ecule lies across an inversion centre. The tetra-zinane ring adopts a chair conformation, and all imino H atoms occupy axial positions. In the crystal, adjacent mol-ecules are linked through O-H⋯O, O-H⋯N and N-H⋯O hydrogen bonds with water mol-ecules generating a three-dimensional network.