[Rheumatoid arthritis: a typical multifactorial genetic disease: review of the literature]

Recenti Prog Med. 2011 Apr;102(4):175-82. doi: 10.1701/624.7291.
[Article in Italian]

Abstract

Environmental factors can be triggers for the clinical appearance of rheumatoid arthritis in subjects with genetic susceptibility. Genetic factors account for 60% of disease susceptibility. This review is focused on the genetic and environmental basis of the susceptibility to arthritis.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Alleles
  • Arthritis, Rheumatoid / epidemiology
  • Arthritis, Rheumatoid / etiology
  • Arthritis, Rheumatoid / genetics*
  • Biomarkers / metabolism
  • Environmental Exposure / adverse effects
  • Evidence-Based Medicine
  • Female
  • Genetic Predisposition to Disease
  • HLA-DR Antigens / genetics
  • Humans
  • Interferon Regulatory Factors / genetics
  • Italy / epidemiology
  • Pregnancy
  • Prevalence
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics
  • Risk Factors
  • Sex Distribution
  • Smoking / adverse effects
  • TNF Receptor-Associated Factor 1 / genetics

Substances

  • Biomarkers
  • HLA-DR Antigens
  • IRF5 protein, human
  • Interferon Regulatory Factors
  • TNF Receptor-Associated Factor 1
  • PTPN22 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22