Generalized verrucosis: a review of the associated diseases, evaluation, and treatments

J Am Acad Dermatol. 2012 Feb;66(2):292-311. doi: 10.1016/j.jaad.2010.12.011. Epub 2011 May 14.

Abstract

Generalized verrucosis has been described in the past as synonymous with epidermodysplasia verruciformis. It has been shown, however, that epidermodysplasia verruciformis and other genetic or immunodeficiency diseases are just a subset of diffuse infections with human papillomavirus termed "generalized verrucosis." This article defines generalized verrucosis and distinct diseases associated with generalized warts. The indications for histopathologic testing, human papillomavirus typing, and other laboratory analyses and potential treatment options are discussed.

Publication types

  • Review

MeSH terms

  • Common Variable Immunodeficiency / complications
  • Common Variable Immunodeficiency / therapy
  • Common Variable Immunodeficiency / virology
  • HIV Infections / complications
  • Humans
  • Hyper-IgM Immunodeficiency Syndrome / complications
  • Hyper-IgM Immunodeficiency Syndrome / therapy
  • Hyper-IgM Immunodeficiency Syndrome / virology
  • Immunologic Deficiency Syndromes / complications
  • Immunologic Deficiency Syndromes / therapy
  • Immunosuppression Therapy / adverse effects
  • Papillomaviridae / genetics
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / therapy
  • Papillomavirus Infections / virology
  • Primary Immunodeficiency Diseases
  • Severe Combined Immunodeficiency / complications
  • Severe Combined Immunodeficiency / therapy
  • Severe Combined Immunodeficiency / virology
  • T-Lymphocytopenia, Idiopathic CD4-Positive / complications
  • T-Lymphocytopenia, Idiopathic CD4-Positive / therapy
  • Warts / complications*
  • Warts / therapy
  • Warts / virology

Supplementary concepts

  • WHIM syndrome