Canine pancreatic clear acinar cell carcinoma showing an unusual mucinous differentiation

S Pavone; E Manuali; C Eleni; A Ferrari; E Bonanno; A Ciorba

doi:10.1016/j.jcpa.2011.03.009

Canine pancreatic clear acinar cell carcinoma showing an unusual mucinous differentiation

J Comp Pathol. 2011 Nov;145(4):355-8. doi: 10.1016/j.jcpa.2011.03.009. Epub 2011 May 14.

Authors

S Pavone¹, E Manuali, C Eleni, A Ferrari, E Bonanno, A Ciorba

Affiliation

¹ Department of Biopathological Science and Hygiene of Animal and Food Production, Faculty of Veterinary Medicine, University of Perugia, Perugia, Italy. pavone.silvia@libero.it

PMID: 21571301
DOI: 10.1016/j.jcpa.2011.03.009

Abstract

A small solitary pancreatic nodule was identified in a 10-year-old mixed breed male dog. Microscopically, the lesion consisted of neoplastic clear acinar cells with diffuse, marked mucin production. Immunohistochemical and ultrastructural investigations confirmed the exocrine acinar origin of the tumour. The tumour was classified as a pancreatic clear acinar cell carcinoma (ACC) showing an unusual mucinous differentiation.

Publication types

Case Reports

MeSH terms

Adenocarcinoma, Clear Cell / chemistry
Adenocarcinoma, Clear Cell / pathology
Adenocarcinoma, Clear Cell / veterinary*
Adenocarcinoma, Mucinous / chemistry
Adenocarcinoma, Mucinous / pathology
Adenocarcinoma, Mucinous / veterinary*
Animals
Biomarkers, Tumor / analysis
Carcinoma, Acinar Cell / chemistry
Carcinoma, Acinar Cell / pathology
Carcinoma, Acinar Cell / veterinary*
Cell Differentiation
Cytoplasmic Granules / ultrastructure
Dog Diseases / metabolism
Dog Diseases / pathology*
Dogs
Male
Microscopy, Electron
Mitotic Index
Pancreatic Neoplasms / chemistry
Pancreatic Neoplasms / pathology
Pancreatic Neoplasms / veterinary*

Substances

Biomarkers, Tumor