Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Jason L Vassy; Peter Shrader; Anna Jonsson; Caroline S Fox; Valeriya Lyssenko; Bo Isomaa; Leif Groop; James B Meigs; Paul W Franks

doi:10.1016/j.diabres.2011.04.013

Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies

Diabetes Res Clin Pract. 2011 Aug;93(2):e76-e79. doi: 10.1016/j.diabres.2011.04.013. Epub 2011 May 12.

Authors

Jason L Vassy¹, Peter Shrader², Anna Jonsson³, Caroline S Fox⁴, Valeriya Lyssenko³, Bo Isomaa⁵, Leif Groop⁶, James B Meigs⁷, Paul W Franks⁸

Affiliations

¹ General Medicine Division, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
² General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.
³ Department of Clinical Sciences, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden.
⁴ Harvard Medical School, Boston, MA, USA; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA, USA.
⁵ Folkhälsan Research Center, Östanpåvägen 32, 68660 Jakobstad, Finland; Department of Social Services and Health Care, PB 111, 68601 Jakobstad, Finland.
⁶ Department of Clinical Sciences, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland.
⁷ General Medicine Division, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
⁸ Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. Electronic address: Paul.Franks@med.lu.se.

Abstract

Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown.

Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study).

Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005.

Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors.

Publication types

Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cohort Studies
Diabetes Mellitus / etiology*
Diabetes Mellitus, Type 2 / etiology*
Finland / epidemiology
Genetic Predisposition to Disease*
Humans
Life Style
Medical History Taking
Middle Aged
Parents*
Risk Factors
United States / epidemiology
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding