Lung cancer is a complicated disease involving many genes and important biologic processes. Genetic variation or aberrant expression of some oncogenes, tumor suppressor genes and DNA repair genes might be related to its incidence and development. How to find out the pathogenic factors of lung cancer and its molecular mechanism of multistage carcinogenesis from massive data is a key question that researchers and clinicians must answer. The bio-chip technology provides a high throughput and efficient method for cancer research. The latest bio-chip progress in lung cancer research is summarized in this minireview.
肺癌的发生发展是多基因共同参与、多途径相互影响的复杂生物学进程，与多种癌基因、抑癌基因、DNA修复基因等变异或表达异常有关。如何从海量数据中寻找肺癌的发病因素和癌变多阶段演进的分子机制，是目前科研和临床工作者必须面对的问题。生物芯片技术的诞生为人们提供了一种高通量、高效率的肿瘤学研究手段。本文将讨论生物芯片技术在肺癌中的最新研究进展。