Metabolic syndrome: is Nlrp3 inflammasome a trigger or a target of insulin resistance?

Circ Res. 2011 May 13;108(10):1160-2. doi: 10.1161/RES.0b013e318220b57b.

Abstract

The Nlrp3 inflammasome has recently been implicated in the development of the metabolic syndrome through the impairment of adipose tissue insulin sensitivity. Recent literature associates Nlrp3 activation with much pathology caused by prolonged insulin resistance state, therefore establishing Nlrp3 as a promising therapeutic target for type-2-diabetes treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / metabolism
  • Carrier Proteins / physiology*
  • Humans
  • Inflammasomes / metabolism
  • Inflammasomes / physiology*
  • Insulin Resistance / physiology*
  • Metabolic Syndrome / metabolism*
  • Metabolic Syndrome / pathology*
  • Mice
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Reactive Oxygen Species / metabolism

Substances

  • Carrier Proteins
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Nlrp3 protein, mouse
  • Reactive Oxygen Species