Abstract
Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Arsenates / chemistry*
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DNA / chemistry*
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Esters
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Hydrolysis
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Kinetics
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Models, Theoretical*
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Quantum Theory
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Solvents / chemistry
Substances
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Arsenates
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Esters
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Solvents
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DNA
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arsenic acid