Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA

Phys Chem Chem Phys. 2011 Jun 21;13(23):10869-71. doi: 10.1039/c1cp20423h. Epub 2011 May 11.

Abstract

Quantum chemical calculations reveal that neither steric hindrance nor less polar solvent medium is able to reduce the otherwise high hydrolysis rate of arsenate-esters. These results question the stability of As-DNA not only in aqueous but also in non-aqueous environments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arsenates / chemistry*
  • DNA / chemistry*
  • Esters
  • Hydrolysis
  • Kinetics
  • Models, Theoretical*
  • Quantum Theory
  • Solvents / chemistry

Substances

  • Arsenates
  • Esters
  • Solvents
  • DNA
  • arsenic acid