Abstract
A palladium-catalyzed cyanation of the 3-position of indole sp(2) C-H bonds by the combination of NH(4)HCO(3) and DMSO as the "CN" source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bicarbonates / chemistry*
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Carbon / chemistry
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Catalysis
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Cyanides / chemistry*
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Dimethyl Sulfoxide / chemistry*
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Hydrogen / chemistry
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Indoles / chemistry*
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Palladium / chemistry*
Substances
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Bicarbonates
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Cyanides
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Indoles
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ammonium bicarbonate
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Palladium
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Carbon
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Hydrogen
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indole
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Dimethyl Sulfoxide