Objective: To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds.
Design: Population-based, cross-sectional analysis.
Setting: The Rotterdam Scan Study.
Participants: A total of 198 persons (age range, 61-95 years) with lobar microbleeds.
Main outcome measures: Distribution of microbleeds over different lobes.
Results: We found that lobar cerebral microbleeds occurred significantly more often in the temporal lobe, a region known to be more affected in cerebral amyloid angiopathy.
Conclusion: This study corroborates the presumed association of lobar microbleeds with cerebral amyloid angiopathy.