Abstract
The Pyrrole derivatives Ia-d were prepared and utilized for the preparation of pyrrolo[2,3-d]pyrimidine derivatives IIa-c, III, IVa-e, V and VIIIa-c; pyrrolo[3,2-e]tetrazolo[1,5-c]pyrimidine VI and pyrrolo[4,3e][1,2,4]triazolo[1,5-c]pyrimidine derivative derivatives VIIa-c. These some newly synthesized compounds were examined for their in vitro antimicrobial activity and in vivo anti-inflammatory. Result indicated that these compounds showed promising anti-inflammatory activity in comparison to ibuprofen (the standard anti-inflammatory drug). The structure-activity relationships (SAR) and anti-inflammatory activities of these compounds are also discussed in this paper.
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Bacillus subtilis / drug effects
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Bacillus subtilis / growth & development
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Carrageenan
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Edema / chemically induced
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Edema / drug therapy*
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Edema / pathology
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Hindlimb
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Ibuprofen / pharmacology
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Male
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Microbial Sensitivity Tests
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Rats
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Rats, Sprague-Dawley
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Pyrimidines
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Pyrroles
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Carrageenan
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Ibuprofen