Maternal plasma noradrenaline levels at 29 weeks and gestational age at birth

Arch Gynecol Obstet. 2011 Dec;284(6):1399-402. doi: 10.1007/s00404-011-1869-y. Epub 2011 Mar 9.

Abstract

Objective: To investigate the relationship between maternal plasma noradrenaline levels at a mean gestational age of 29 weeks and gestational age and weight at birth.

Design: Original research.

Sample: Seventy-four pregnant women with a mean gestational age of 29 weeks.

Methods: Psychological anxiety levels (Spielberger State and Trait questionnaire) and plasma stress hormone levels (noradrenaline and adrenaline) were measured in pregnant women at a mean gestational age of 29 weeks. Statistical analysis was applied to investigate links between these variables and gestational age and weight at birth.

Outcome measures: Self-rating anxiety, State and Trait Spielberger questionnaire, maternal noradrenaline and adrenaline levels, gestational age and weight at birth.

Results: There was a significant inverse relationship between maternal noradrenaline levels and the infant gestational age at birth (r = 0.09, p = 0.05). There was no relationship between maternal noradrenaline levels and weight at birth.

Conclusions: There was a significant inverse relationship between maternal noradrenaline levels and gestational age at birth, suggesting the possibility of underlying mechanisms linking maternal noradrenaline and timing of delivery.

MeSH terms

  • Adult
  • Anxiety / blood
  • Birth Weight*
  • Female
  • Gestational Age*
  • Humans
  • Infant, Newborn
  • Norepinephrine / blood*
  • Pregnancy
  • Pregnancy Trimester, Third / blood*
  • Surveys and Questionnaires

Substances

  • Norepinephrine