Convergent strategies in biosynthesis

Nat Prod Rep. 2011 Jun;28(6):1054-86. doi: 10.1039/c0np00047g. Epub 2011 May 6.

Abstract

This review article focuses on how nature sometimes solves the same problem in the biosynthesis of small molecules but using very different approaches. Four examples, involving isopentenyl diphosphate, menaquinone, lysine, and aromatic polyketides, are highlighted that represent different strategies in convergent metabolism.

Publication types

  • Review

MeSH terms

  • Bacteria / chemistry
  • Bacteria / enzymology
  • Bacteria / metabolism
  • Biological Products / biosynthesis*
  • Biological Products / chemistry
  • Lysine / biosynthesis
  • Lysine / chemistry
  • Macrolides / chemistry
  • Macrolides / metabolism
  • Molecular Structure
  • Terpenes / chemistry
  • Terpenes / metabolism
  • Vitamin K 2 / chemistry
  • Vitamin K 2 / metabolism

Substances

  • Biological Products
  • Macrolides
  • Terpenes
  • Vitamin K 2
  • Lysine