Evaluation of sugammadex self-association

Sergey V Kurkov; Martin Messner; Marjoleine Lucassen; Diels J van den Dobbelsteen; John den Engelsman; Thorsteinn Loftsson

doi:10.1016/j.ijpharm.2011.04.044

Evaluation of sugammadex self-association

Int J Pharm. 2011 Jul 15;413(1-2):134-9. doi: 10.1016/j.ijpharm.2011.04.044. Epub 2011 Apr 22.

Authors

Sergey V Kurkov¹, Martin Messner, Marjoleine Lucassen, Diels J van den Dobbelsteen, John den Engelsman, Thorsteinn Loftsson

Affiliation

¹ Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, Iceland.

PMID: 21539905
DOI: 10.1016/j.ijpharm.2011.04.044

Abstract

Sugammadex, a thiolated γCD derivative used as an antagonist of steroidal blockers, was studied with regard to its tendency to self-associate in aqueous solution. Three independent methods - permeation through semi-permeable cellophane membranes, dynamic light scattering, and sedimentation equilibrium analytical ultracentrifugation - were used for this purpose. The results were in agreement with each other and showed no evidence of self-association in a wide sugammadex concentration range from 0.25 to 100mg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cellophane / chemistry
Dose-Response Relationship, Drug
Neuromuscular Blocking Agents / antagonists & inhibitors
Pharmaceutical Solutions / chemistry
Solutions / chemistry
Sugammadex
Time Factors
Ultracentrifugation / methods
gamma-Cyclodextrins / analysis
gamma-Cyclodextrins / chemistry*

Substances

Neuromuscular Blocking Agents
Pharmaceutical Solutions
Solutions
gamma-Cyclodextrins
Sugammadex
Cellophane