Abstract
The Hippo pathway coordinates organ size and cell proliferation. The retinoblastoma family of proteins regulates progression through the G0/G1 phase of the cell cycle. Disruption of either pathway contributes to cancer formation. Three recent studies in Genes & Development reveal how cellular proliferation is coordinated between these pathways. Here we discuss the implications of these studies and the new questions that they raise.
Publication types
-
Research Support, Non-U.S. Gov't
-
Comment
MeSH terms
-
Animals
-
Cell Cycle / physiology
-
Cellular Senescence / physiology
-
Dyrk Kinases
-
Embryonic Development / genetics
-
Embryonic Development / physiology
-
Gene Expression Regulation
-
Humans
-
Kv Channel-Interacting Proteins / metabolism*
-
Neoplasms / physiopathology
-
Organ Size / physiology
-
Protein Serine-Threonine Kinases / metabolism*
-
Protein-Tyrosine Kinases / metabolism
-
Retinoblastoma Protein / metabolism
-
Retinoblastoma-Like Protein p130 / genetics
-
Retinoblastoma-Like Protein p130 / metabolism
-
Signal Transduction
Substances
-
Kv Channel-Interacting Proteins
-
Retinoblastoma Protein
-
Retinoblastoma-Like Protein p130
-
Protein-Tyrosine Kinases
-
Protein Serine-Threonine Kinases