Abstract
Nanogels are comprised of swollen polymer networks and nearly 95% water and can entrap diverse chemical and biological agents for cancer therapy with very high loading capacities. Here we use diblock copolymer poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) to form nanogels with the desired degree of cross-linking. The nanogels are further conjugated to folic acid (FA) and loaded with different types of drugs (cisplatin, doxorubicin). For the first time we demonstrate a tumor-specific delivery and superior anti-tumor effect in vivo of an anti-cancer drug using these polyelectrolyte nanogels decorated with folate-targeting groups. This reinforces the use of nanogels for the therapy of ovarian and other cancers, where folate receptor (FR) is overexpressed.
Copyright © 2011. Published by Elsevier Ltd.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use*
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Biological Availability
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Body Weight / drug effects
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Cell Line, Tumor
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Cell Survival / drug effects
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Cisplatin / administration & dosage
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Cisplatin / chemistry
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Cisplatin / pharmacokinetics
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Cisplatin / pharmacology
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Cisplatin / therapeutic use
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Doxorubicin / administration & dosage
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Doxorubicin / chemistry
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Doxorubicin / pharmacokinetics
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Doxorubicin / pharmacology
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Doxorubicin / therapeutic use
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Drug Delivery Systems / methods*
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Endocytosis / physiology
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Female
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Folic Acid / chemistry*
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Humans
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Hydrogels / chemical synthesis
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Hydrogels / chemistry*
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Hydrogen-Ion Concentration
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Inhibitory Concentration 50
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Light
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Mice
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Mice, Nude
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Microscopy, Atomic Force
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Nanoparticles / chemistry*
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Osmolar Concentration
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Ovarian Neoplasms / drug therapy*
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Ovarian Neoplasms / metabolism
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Ovarian Neoplasms / pathology
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Particle Size
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Platinum / metabolism
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Polyethylene Glycols / chemistry
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Polymethacrylic Acids / chemistry
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Scattering, Radiation
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Static Electricity
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Surface Properties
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Survival Analysis
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Water / chemistry
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents
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Hydrogels
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Polymethacrylic Acids
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poly(ethylene oxide)-b-poly(methacrylic acid)
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Water
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Polyethylene Glycols
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Platinum
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Doxorubicin
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Folic Acid
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Cisplatin