Synthesis of conjugates of polyhedral boron compounds with tumor-seeking molecules for neutron capture therapy

V Bregadze; A Semioshkin; I Sivaev

doi:10.1016/j.apradiso.2011.01.043

Synthesis of conjugates of polyhedral boron compounds with tumor-seeking molecules for neutron capture therapy

Appl Radiat Isot. 2011 Dec;69(12):1774-7. doi: 10.1016/j.apradiso.2011.01.043. Epub 2011 Apr 12.

Authors

V Bregadze¹, A Semioshkin, I Sivaev

Affiliation

¹ AN Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia. bre@ineos.ac.ru

PMID: 21531143
DOI: 10.1016/j.apradiso.2011.01.043

Abstract

Recent achievements in design and synthesis of boronated acids, amino acids, glycerols as well as conjugates of polyhedral boron hydrides (ortho-carborane, closo-dodecaborate and cobalt bis(dicarbollide)) with natural porphyrins, carbohydrates and nucleosides are described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Boron Compounds / chemistry*
Boron Neutron Capture Therapy*
Humans
Neoplasms / radiotherapy*

Substances

Boron Compounds