Tambjamine alkaloids and related synthetic analogs: efficient transmembrane anion transporters

Chem Commun (Camb). 2012 Feb 1;48(10):1556-8. doi: 10.1039/c1cc11300c. Epub 2011 Apr 28.

Abstract

The tambjamine alkaloids and related synthetic analogs are potent transmembrane anion tranporters promoting bicarbonate/chloride exchange in model phospholipid liposomes and discharging pH gradients in living cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis
  • Alkaloids / chemistry*
  • Alkaloids / pharmacokinetics*
  • Bicarbonates / chemistry
  • Biological Transport / drug effects
  • Cell Line, Tumor
  • Cell Membrane / chemistry
  • Cell Membrane / drug effects*
  • Chlorides / chemistry
  • Humans
  • Hydrogen-Ion Concentration
  • Liposomes / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Phospholipids / chemistry
  • Pyrroles / chemical synthesis
  • Pyrroles / chemistry*
  • Pyrroles / pharmacokinetics*

Substances

  • Alkaloids
  • Bicarbonates
  • Chlorides
  • Liposomes
  • Phospholipids
  • Pyrroles