Abstract
The tambjamine alkaloids and related synthetic analogs are potent transmembrane anion tranporters promoting bicarbonate/chloride exchange in model phospholipid liposomes and discharging pH gradients in living cells.
This journal is © The Royal Society of Chemistry 2012
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemical synthesis
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Alkaloids / chemistry*
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Alkaloids / pharmacokinetics*
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Bicarbonates / chemistry
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Biological Transport / drug effects
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Cell Line, Tumor
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Cell Membrane / chemistry
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Cell Membrane / drug effects*
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Chlorides / chemistry
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Humans
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Hydrogen-Ion Concentration
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Liposomes / chemistry*
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Models, Molecular
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Molecular Structure
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Phospholipids / chemistry
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Pyrroles / chemical synthesis
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Pyrroles / chemistry*
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Pyrroles / pharmacokinetics*
Substances
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Alkaloids
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Bicarbonates
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Chlorides
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Liposomes
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Phospholipids
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Pyrroles