The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin

Chem Commun (Camb). 2011 Jun 7;47(21):6006-8. doi: 10.1039/c1cc11627d. Epub 2011 Apr 28.

Abstract

Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antineoplastic Agents / chemistry*
  • Binding Sites
  • Chromatography, High Pressure Liquid
  • Cisplatin / chemistry*
  • Humans
  • Mass Spectrometry
  • Protein Structure, Tertiary
  • Serum Albumin / chemistry*
  • Zinc / chemistry*

Substances

  • Antineoplastic Agents
  • Serum Albumin
  • Zinc
  • Cisplatin