Abstract
Cisplatin, cis-[Pt(Cl(2)(NH(3))(2)], can crosslink residues His67 of domain I and His247 of domain II in human albumin, occupying the major binding site for the essential metal zinc on the protein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antineoplastic Agents / chemistry*
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Binding Sites
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Chromatography, High Pressure Liquid
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Cisplatin / chemistry*
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Humans
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Mass Spectrometry
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Protein Structure, Tertiary
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Serum Albumin / chemistry*
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Zinc / chemistry*
Substances
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Antineoplastic Agents
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Serum Albumin
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Zinc
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Cisplatin