New antiplasmodial indole alkaloids from Hunteria zeylanica

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3417-9. doi: 10.1016/j.bmcl.2011.03.104. Epub 2011 Apr 5.

Abstract

Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent antiplasmodial activity against Plasmodium falciparum 3D7.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / chemistry*
  • Antimalarials / pharmacology*
  • Apocynaceae / chemistry*
  • Circular Dichroism
  • HL-60 Cells
  • Humans
  • Indole Alkaloids / chemistry*
  • Indole Alkaloids / pharmacology*
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Bark / chemistry*
  • Plasmodium falciparum / drug effects*

Substances

  • Antimalarials
  • Indole Alkaloids