Immobility due to sitting position during traveling is a well-known risk factor for venous thromboembolism (VTE). Beasley et al. (2003) first proposed the name "eThrombosis" for a case in which VTE was related to prolonged seated immobility at computer. We present clinical and laboratory data of six patients with "eThrombosis". As this kind of immobility probably plays an underestimated role in VTE development, other risk factors can also be usually found. "eThrombosis" affects mainly young people, but it may occur at any age. Limited time of seated immobility, intervals for physical exercise and graduated compression stockings use are forms of "eThrombosis" prophylaxis.