The title compound, C(28)H(24)N(4)O(4)·H(2)O, crystallizes with two organic mol-ecules and two solvent water mol-ecules in the asymmetric unit. The most obvious difference between the mol-ecules is the torsion angles between the isoxazole ring and the benzene and phenyl rings [47.0 (2)/56.4 (2) and 33.3 (2)/11.0 (2)°, respectively]. Another important difference is observed in the rotation of the nitro group with respect to the phenyl groups [3.5 (6) and 31.1 (6)°]. The pyrrolidinone fragment is cis oriented with respect to the 4-nitro-phenyl fragment. In the crystal, mol-ecules are linked into centrosymmetric R(4) (2)(8) and R(4) (4)(20) motifs by O-H⋯O and N-H⋯O inter-actions.