Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

Yasutaka Anraku; Akihiro Kishimura; Atsushi Kobayashi; Makoto Oba; Kazunori Kataoka

doi:10.1039/c1cc11465d

Size-controlled long-circulating PICsome as a ruler to measure critical cut-off disposition size into normal and tumor tissues

Chem Commun (Camb). 2011 Jun 7;47(21):6054-6. doi: 10.1039/c1cc11465d. Epub 2011 Apr 26.

Authors

Yasutaka Anraku¹, Akihiro Kishimura, Atsushi Kobayashi, Makoto Oba, Kazunori Kataoka

Affiliation

¹ Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

PMID: 21519616
DOI: 10.1039/c1cc11465d

Abstract

Selective disposition of nanocarriers into target tissue is an essential issue in drug delivery. Critical size of nanocarriers (∼150 nm) discriminating the permeability into normal and tumor tissues was determined by the use of size-tunable, polyion complex hollow vesicles (PICsome) as a ruler.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carbocyanines / chemistry
Drug Carriers / chemistry*
Drug Carriers / therapeutic use
Mice
Mice, Nude
Nanoparticles / chemistry*
Nanoparticles / therapeutic use
Neoplasms / drug therapy
Particle Size
Polyethylene Glycols / chemistry

Substances

Carbocyanines
Drug Carriers
cyanine dye 5
Polyethylene Glycols