Multiple cerebral arterial stenosis associated with hepatitis B virus infection

J Clin Neurol. 2011 Mar;7(1):40-2. doi: 10.3988/jcn.2011.7.1.40. Epub 2011 Mar 31.

Abstract

Background: There are conflicting findings regarding the association between hepatitis B (HB) virus (HBV) infection and atherosclerosis.

Case report: A 34-year-old man was admitted for transient dysarthria and facial palsy. Ten years previously he had been diagnosed with HBV infection and treated with lamivudine (100 mg/day). Reactivation of HBV was detected 6 months before this recent admission. Serologic tests revealed that he was positive for HB early antigen, HB surface antigen, and anti-HB core. Brain magnetic resonance images were normal, but magnetic resonance angiograms revealed severe stenosis of the right middle cerebral artery, both external carotid arteries, and the basilar artery.

Conclusions: This case report reveals that a young patient with reactivated HBV developed multiple arterial stenoses even though he had no risk factors for this disease.

Keywords: atherosclerosis; hepatitis B virus; multiple cerebral arterial stenoses; reactivated HBV infection.