Abstract
Dronedarone is a relatively new antiarrhythmic drug approved for paroxysmal or persistent atrial fibrillation. Dronedarone can inhibit P-glycoprotein-mediated digoxin clearance and increase steady-state digoxin level 2.5 times. It is important to closely monitor plasma digoxin levels or administer a lower loading dose of digoxin in patients taking dronedarone concomitantly. We report a case of digoxin toxicity in a patient taking concomitant dronedarone as a result of interaction between digoxin and dronedarone.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
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Aged, 80 and over
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Amiodarone / adverse effects
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Amiodarone / analogs & derivatives*
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Amiodarone / pharmacology
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Amiodarone / therapeutic use
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Anti-Arrhythmia Agents / adverse effects*
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Anti-Arrhythmia Agents / pharmacokinetics
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Anti-Arrhythmia Agents / therapeutic use
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Atrial Fibrillation / drug therapy
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Digoxin / adverse effects*
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Digoxin / pharmacokinetics
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Digoxin / therapeutic use
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Dose-Response Relationship, Drug
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Dronedarone
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Drug Interactions
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Drug Monitoring / methods
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Female
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Humans
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Anti-Arrhythmia Agents
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Digoxin
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Dronedarone
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Amiodarone