Dronedarone-induced digoxin toxicity: new drug, new interactions

Am J Ther. 2013 Nov-Dec;20(6):e717-9. doi: 10.1097/MJT.0b013e31821106c9.

Abstract

Dronedarone is a relatively new antiarrhythmic drug approved for paroxysmal or persistent atrial fibrillation. Dronedarone can inhibit P-glycoprotein-mediated digoxin clearance and increase steady-state digoxin level 2.5 times. It is important to closely monitor plasma digoxin levels or administer a lower loading dose of digoxin in patients taking dronedarone concomitantly. We report a case of digoxin toxicity in a patient taking concomitant dronedarone as a result of interaction between digoxin and dronedarone.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / drug effects
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Aged, 80 and over
  • Amiodarone / adverse effects
  • Amiodarone / analogs & derivatives*
  • Amiodarone / pharmacology
  • Amiodarone / therapeutic use
  • Anti-Arrhythmia Agents / adverse effects*
  • Anti-Arrhythmia Agents / pharmacokinetics
  • Anti-Arrhythmia Agents / therapeutic use
  • Atrial Fibrillation / drug therapy
  • Digoxin / adverse effects*
  • Digoxin / pharmacokinetics
  • Digoxin / therapeutic use
  • Dose-Response Relationship, Drug
  • Dronedarone
  • Drug Interactions
  • Drug Monitoring / methods
  • Female
  • Humans

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Anti-Arrhythmia Agents
  • Digoxin
  • Dronedarone
  • Amiodarone