Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level

J Biosci Bioeng. 2011 Jul;112(1):40-3. doi: 10.1016/j.jbiosc.2011.03.010. Epub 2011 Apr 21.

Abstract

A gene encoding the Zn(II)(2)Cys(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of KA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus oryzae / genetics
  • Aspergillus oryzae / metabolism*
  • Cysteine / biosynthesis
  • Cysteine / genetics
  • Cysteine / metabolism
  • DNA, Fungal / metabolism
  • Fungal Proteins / biosynthesis
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal / drug effects*
  • Genes, Fungal
  • Pyrones / metabolism*
  • Trans-Activators / metabolism
  • Transcription Factors / biosynthesis
  • Transcriptional Activation / drug effects

Substances

  • DNA, Fungal
  • Fungal Proteins
  • Pyrones
  • Trans-Activators
  • Transcription Factors
  • kojic acid
  • Cysteine