Abstract
A gene encoding the Zn(II)(2)Cys(6) transcriptional factor is clustered with two genes involved in biosynthesis of a secondary metabolite, kojic acid (KA), in Aspergillus oryzae. We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of KA.
Copyright © 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aspergillus oryzae / genetics
-
Aspergillus oryzae / metabolism*
-
Cysteine / biosynthesis
-
Cysteine / genetics
-
Cysteine / metabolism
-
DNA, Fungal / metabolism
-
Fungal Proteins / biosynthesis
-
Fungal Proteins / genetics
-
Fungal Proteins / metabolism
-
Gene Expression Regulation, Fungal / drug effects*
-
Genes, Fungal
-
Pyrones / metabolism*
-
Trans-Activators / metabolism
-
Transcription Factors / biosynthesis
-
Transcriptional Activation / drug effects
Substances
-
DNA, Fungal
-
Fungal Proteins
-
Pyrones
-
Trans-Activators
-
Transcription Factors
-
kojic acid
-
Cysteine