[Influence duration of the use of estrogens beyond the menses in estradiol IVF antagonist programming cycles]

J Gynecol Obstet Biol Reprod (Paris). 2011 Oct;40(6):498-502. doi: 10.1016/j.jgyn.2011.03.003. Epub 2011 Apr 21.
[Article in French]

Abstract

Objective: To evaluate by the birth rate the impact of the number of days of estrogens continued beyond the menses in a four days estradiol IVF antagonist programming cycles.

Patients and methods: Retrospective study from September 2004 to January 2009 among women of age ranging between 25 and 38 years. Four milligrams of provames is prescribed 3 to 5 days before the theorical menses and continued until the beginning day of stimulation, which is distributed equitably between Thursday and Sunday. The birth rate is evaluated according to the number of days of estrogen continued beyond the menses within a limit from 1 to 8.

Results: No significant difference appears neither in the duration of stimulation, in the quantity of gonadotrophin, the oocytes pick up, nor in the rate of birth between the groups.

Conclusion: The programming by estrogens of the antagonist IVF cycles implies a variable number of days of estrogens continued beyond the menses, which does not seem to affect the birth rate.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Drug Administration Schedule
  • Estrogen Antagonists / adverse effects
  • Estrogen Antagonists / therapeutic use*
  • Estrogens / administration & dosage*
  • Estrogens / adverse effects
  • Estrogens / pharmacology
  • Female
  • Fertility Agents, Female / adverse effects
  • Fertility Agents, Female / therapeutic use
  • Fertilization in Vitro / methods*
  • Gonadotropins / adverse effects
  • Gonadotropins / pharmacology
  • Gonadotropins / therapeutic use
  • Humans
  • Menstrual Cycle / drug effects
  • Menstrual Cycle / physiology
  • Menstruation / drug effects*
  • Menstruation / physiology
  • Ovulation Induction / methods*
  • Periodicity
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Time Factors

Substances

  • Estrogen Antagonists
  • Estrogens
  • Fertility Agents, Female
  • Gonadotropins