Coverage of large skin defects, especially following tumor resection and in patients who are not good candidates for procedures requiring general anesthesia, may require a staged procedure. The use of dermal substitutes to cover the defect until autologous grafting can be performed has been described. Hyaluronic acid biological dressings (HABD) also have been used for the temporary coverage of partial- to full-thickness posttraumatic or postsurgical wounds. An 82-year-old man with cardiopathy presented with an 8 cm x 4 cm ulcerated squamous cell carcinoma on his forehead. Following surgical removal under local anesthesia, the 12 cm x 8 cm defect was covered with HABD, which was removed immediately before the scheduled surgical closure (21 days later). At that time, well-vascularized granulation tissue completely covered the bone and an autologous skin graft was applied. Punch biopsy results obtained 4 weeks after surgery showed dressing remnants in the dermis and confirmed the graft was totally integrated with the surrounding tissues; there was no evidence of hypertrophy or excessive scarring. In this patient, the staged procedure provided an excellent alternative to a complex surgical procedure. Use of the biological dressing required only a weekly wound and dressing assessment and the cosmetic result was good without evidence of a recurrence at the 2-year follow-up. Studies to ascertain the efficacy and effectiveness of this dressing for the temporary coverage of soft tissue defects are needed.