Carbamazepine induced DRESS syndrome

J Assoc Physicians India. 2010 Oct:58:634-6.

Abstract

We present here an 18-yr-old male who presented with intermittent fever of moderate grade and of 15 days duration, followed by maculopapular erythematous rashes over upper and lower extremities, face, and trunk developing over 10-12 days. He was suffering from recurrent seizures since last 3 months for which he was started on carbamazepine 200mg twice daily for the past 6 weeks. He was febrile on admission. Generalized lymphadenopathy with discreet, non-matted, firm and tender inguinal lymph nodes. Patch test with 1% and 5% solution of carbamazepine was strongly positive.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anticonvulsants / adverse effects*
  • Biopsy
  • Carbamazepine / adverse effects*
  • Dermatitis, Exfoliative / chemically induced*
  • Dermatitis, Exfoliative / complications
  • Drug Eruptions
  • Drug Hypersensitivity
  • Eosinophilia / chemically induced*
  • Eosinophilia / complications
  • Epilepsy / drug therapy*
  • Exanthema / chemically induced*
  • Exanthema / complications
  • Humans
  • Hyperthermia, Induced
  • Lymphatic Diseases / chemically induced*
  • Lymphatic Diseases / complications
  • Male
  • Patch Tests
  • Skin Tests
  • Syndrome
  • Treatment Outcome

Substances

  • Anticonvulsants
  • Carbamazepine