[Efficacy and safety of high dose (≥8 mg/kg/day) daptomycin]

Abstract

Introduction: There is a paucity of data regarding efficacy and safety of high dose (>8mg/kg/day) daptomycin.

Material and methods: This ambispective study included all patients that received ≥8 mg/kg/day of daptomycin and had efficacy and safety data.

Results: Sixty-nine patients were included. Fifty-nine patients (85.5%) were recorded as having been cured or improved. Six patients (8.6%) had a raised CPK during follow-up with no clinical signs of myopathy in any of them.

Conclusions: High dose daptomycin shows good efficacy without concerns about toxicity.