Myopathy and neurogenic muscular atrophy in unexpected cardiopulmonary arrest

Hisashi Kawashima; Chiako Ishii; Gaku Yamanaka; Hiroaki Ioi; Shigeo Nishimata; Yasuyo Kashiwagi; Kouji Takekuma; Tasuku Miyajima; Akinori Hoshika; Ichizo Nishino; Ikuya Nonaka

doi:10.1111/j.1442-200X.2010.03211.x

Myopathy and neurogenic muscular atrophy in unexpected cardiopulmonary arrest

Pediatr Int. 2011 Apr;53(2):159-61. doi: 10.1111/j.1442-200X.2010.03211.x.

Authors

Hisashi Kawashima¹, Chiako Ishii, Gaku Yamanaka, Hiroaki Ioi, Shigeo Nishimata, Yasuyo Kashiwagi, Kouji Takekuma, Tasuku Miyajima, Akinori Hoshika, Ichizo Nishino, Ikuya Nonaka

Affiliation

¹ Department of Pediatrics, Tokyo Medical University Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. hisashi@tokyo-med.ac.jp

PMID: 21501304
DOI: 10.1111/j.1442-200X.2010.03211.x

Abstract

Background: Neuromuscular disorders can be the cause of sudden death of infants because of their weakness and gastroesophageal reflux (GER).

Methods: Muscle biopsy and genetic studies were performed by usual method.

Results: In this report four cases of infants with neuromuscular disorders (two cases of congenital myopathy and two cases of spinal muscular atrophy) who had unexpected cardiopulmonary arrest on arrival (CPAOA) are presented. Two of the cases did not show any symptoms, such as muscle weakness prior to CPAOA. The diagnosis was based on the results of the muscle biopsy and genetic examination.

Conclusion: These results suggest that sudden infant death caused by neuromuscular disorders should be considered.

Publication types

Case Reports

MeSH terms

Female
Heart Arrest / etiology*
Humans
Infant
Infant, Newborn
Male
Muscular Diseases / complications*
Myopathies, Nemaline / complications
Myopathies, Structural, Congenital
Spinal Muscular Atrophies of Childhood / complications*
Sudden Infant Death / etiology*