Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

Dana A Uhlenheuer; Jacqui F Young; Hoang D Nguyen; Marcel Scheepstra; Luc Brunsveld

doi:10.1039/c1cc11197c

Cucurbit[8]uril induced heterodimerization of methylviologen and naphthalene functionalized proteins

Chem Commun (Camb). 2011 Jun 28;47(24):6798-800. doi: 10.1039/c1cc11197c. Epub 2011 Apr 18.

Authors

Dana A Uhlenheuer¹, Jacqui F Young, Hoang D Nguyen, Marcel Scheepstra, Luc Brunsveld

Affiliation

¹ Laboratory of Chemical Biology, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.

PMID: 21499633
DOI: 10.1039/c1cc11197c

Abstract

Cucurbit[8]uril is a supramolecular inducer of protein heterodimerization for proteins appended with methylviologen and naphthalene host elements. Two sets of fluorescent protein pairs, which visualize the specific protein assembly process, enabled the interplay of the supramolecular elements with the proteins to be established.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bridged-Ring Compounds / metabolism*
Imidazoles / metabolism*
Luminescent Proteins / chemistry
Luminescent Proteins / metabolism*
Naphthalenes / chemistry
Naphthalenes / metabolism*
Paraquat / chemistry
Paraquat / metabolism*
Protein Multimerization
Spectrometry, Fluorescence

Substances

Bridged-Ring Compounds
Imidazoles
Luminescent Proteins
Naphthalenes
cucurbit(8)uril
naphthalene
Paraquat