Syntheses, structures and antimicrobial activities of bis(imino)acenaphthene (BIAN) imidazolium salts

Molecules. 2011 Apr 15;16(4):3168-78. doi: 10.3390/molecules16043168.

Abstract

The syntheses of four new bis(imino)acenaphthene (BIAN) imidazolium chlorides are reported, three of which have been structurally characterized. The synthesis of a new, structurally authenticated BIAN ligand is also described. We report the results of the use of these BIAN imidazolium salts as antimicrobials against the pathogens S. aureus, B. subtilis, E. coli and P. aeruginosa. The antimicrobial efficacies were particularly high for the N-(2,6-diisopropylphenyl)- and N-(mesityl)-substituted BIAN imidazolium salts (MIC values < 0.6 μg/mL).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acenaphthenes / chemical synthesis
  • Acenaphthenes / chemistry*
  • Acenaphthenes / pharmacology*
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus subtilis / drug effects
  • Crystallography, X-Ray
  • Imidazoles / chemical synthesis
  • Imidazoles / chemistry*
  • Imidazoles / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Staphylococcus aureus / drug effects

Substances

  • Acenaphthenes
  • Anti-Bacterial Agents
  • Imidazoles
  • acenaphthene