The search for neuroimaging biomarkers of Alzheimer's disease with advanced MRI techniques

Acta Radiol. 2011 Mar 1;52(2):211-22. doi: 10.1258/ar.2010.100053.

Abstract

The aim of this review is to examine the recent literature on using advanced magnetic resonance imaging (MRI) techniques for finding neuroimaging biomarkers that are sensitive to the detection of risks for Alzheimer's disease (AD). Since structural MRI techniques, such as brain structural volumetry and voxel-based morphometry (VBM), have been widely used for AD studies and extensively reviewed, we will only briefly touch on the topics of volumetry and morphometry. The focus of the current review is about the more recent developments in the search for AD neuroimaging biomarkers with functional MRI (fMRI), resting-state functional connectivity MRI (fcMRI), diffusion tensor imaging (DTI), arterial spin-labeling (ASL), and magnetic resonance spectroscopy (MRS).

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / pathology*
  • Biomarkers
  • Brain / pathology*
  • Diffusion Magnetic Resonance Imaging / methods
  • Humans
  • Imaging, Three-Dimensional / methods
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods
  • Spin Labels

Substances

  • Biomarkers
  • Spin Labels