Abstract
The biosynthetic pathways to a number of natural products have been reconstituted in vitro using purified enzymes. Many of these molecules have also been synthesized by organic chemists. Here we compare the strategies used by nature and by chemists to reveal the underlying logic and success of each total synthetic approach for some exemplary molecules with diverse biosynthetic origins.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alkaloids / biosynthesis
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Alkaloids / chemical synthesis
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Alkaloids / chemistry
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Bacteria / enzymology
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Biomimetics / methods
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Phenazines / chemical synthesis
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Phenazines / chemistry
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Phenazines / metabolism
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Plants / enzymology
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Sesquiterpenes / chemical synthesis
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Sesquiterpenes / chemistry
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Sesquiterpenes / metabolism
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Siderophores / biosynthesis
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Siderophores / chemical synthesis
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Siderophores / chemistry
Substances
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Alkaloids
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Biological Products
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Phenazines
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Sesquiterpenes
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Siderophores