Zinc-chelated imidazole groups for DNA polyion complex formation

Metallomics. 2011 Jul;3(7):680-2. doi: 10.1039/c1mt00019e. Epub 2011 Apr 14.

Abstract

This communication presents the pH-dependent chelation of Zn(2+) ions with the imidazole groups of poly(1-vinylimidazole) (PVIm) and DNA polyion complex formation with the zinc-chelated PVIm (PVIm-Zn) via chelated Zn(2+) ions. The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression.

MeSH terms

  • Chelating Agents / chemistry
  • Chelating Agents / metabolism*
  • DNA / metabolism*
  • Electrophoresis, Agar Gel
  • Hep G2 Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Imidazoles / chemistry
  • Imidazoles / metabolism*
  • Ions
  • Polyvinyls / chemistry
  • Polyvinyls / metabolism*
  • Zinc / chemistry
  • Zinc / metabolism*

Substances

  • Chelating Agents
  • Imidazoles
  • Ions
  • Polyvinyls
  • poly(1-vinylimidazole)
  • DNA
  • Zinc