Abstract
This communication presents the pH-dependent chelation of Zn(2+) ions with the imidazole groups of poly(1-vinylimidazole) (PVIm) and DNA polyion complex formation with the zinc-chelated PVIm (PVIm-Zn) via chelated Zn(2+) ions. The resulting PVIm-Zn/DNA complexes exhibit no significant cytotoxicity and show outstanding gene expression.
MeSH terms
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Chelating Agents / chemistry
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Chelating Agents / metabolism*
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DNA / metabolism*
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Electrophoresis, Agar Gel
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Hep G2 Cells
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Humans
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Hydrogen-Ion Concentration
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Imidazoles / chemistry
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Imidazoles / metabolism*
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Ions
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Polyvinyls / chemistry
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Polyvinyls / metabolism*
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Zinc / chemistry
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Zinc / metabolism*
Substances
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Chelating Agents
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Imidazoles
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Ions
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Polyvinyls
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poly(1-vinylimidazole)
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DNA
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Zinc