Abstract
A cell specific peptide (Arg-Gly-Asp; RGD)-modified nanogel was prepared and evaluated for its potential to act as a protein delivery carrier. A bovine serum albumin (BSA)/RGD-modified nanogel complex was efficiently internalized into cells through integrin-mediated endocytosis. Endosomal escape of the RGD-modified nanogel was observed after 24 h incubation. The nanogel proved useful for targeted protein delivery.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Clathrin / pharmacology
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Endocytosis
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HeLa Cells
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Humans
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Integrins
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Nanogels
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Oligopeptides / chemical synthesis*
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Oligopeptides / metabolism
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Pinocytosis
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Polyethylene Glycols / chemical synthesis*
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Polyethylene Glycols / metabolism
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Polyethyleneimine / chemical synthesis*
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Polyethyleneimine / metabolism
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Protein Transport
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Proteoglycans / chemical synthesis*
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Proteoglycans / metabolism
Substances
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Clathrin
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Integrins
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Nanogels
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Oligopeptides
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Proteoglycans
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polyethylene glycol polyethyleneimine nanogel
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polysaccharide peptide
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Polyethylene Glycols
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arginyl-glycyl-aspartic acid
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Polyethyleneimine