Cell specific peptide-conjugated polysaccharide nanogels for protein delivery

Macromol Biosci. 2011 Jul 7;11(7):882-8. doi: 10.1002/mabi.201000491. Epub 2011 Apr 13.

Abstract

A cell specific peptide (Arg-Gly-Asp; RGD)-modified nanogel was prepared and evaluated for its potential to act as a protein delivery carrier. A bovine serum albumin (BSA)/RGD-modified nanogel complex was efficiently internalized into cells through integrin-mediated endocytosis. Endosomal escape of the RGD-modified nanogel was observed after 24 h incubation. The nanogel proved useful for targeted protein delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Clathrin / pharmacology
  • Endocytosis
  • HeLa Cells
  • Humans
  • Integrins
  • Nanogels
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / metabolism
  • Pinocytosis
  • Polyethylene Glycols / chemical synthesis*
  • Polyethylene Glycols / metabolism
  • Polyethyleneimine / chemical synthesis*
  • Polyethyleneimine / metabolism
  • Protein Transport
  • Proteoglycans / chemical synthesis*
  • Proteoglycans / metabolism

Substances

  • Clathrin
  • Integrins
  • Nanogels
  • Oligopeptides
  • Proteoglycans
  • polyethylene glycol polyethyleneimine nanogel
  • polysaccharide peptide
  • Polyethylene Glycols
  • arginyl-glycyl-aspartic acid
  • Polyethyleneimine