Single wall carbon nanotubes block ion passage in mechano-sensitive ion channels by interacting with extracellular domain

Ashish Patel; Suchi Smita; Qamar Rahman; Shailendra K Gupta; Mukesh K Verma

doi:10.1166/jbn.2011.1260

Single wall carbon nanotubes block ion passage in mechano-sensitive ion channels by interacting with extracellular domain

J Biomed Nanotechnol. 2011 Feb;7(1):183-5. doi: 10.1166/jbn.2011.1260.

Authors

Ashish Patel¹, Suchi Smita, Qamar Rahman, Shailendra K Gupta, Mukesh K Verma

Affiliation

¹ Sub-DIC Bioinformatics, National Institute of Technology Raipur, Chhattisgarh 492010, India.

PMID: 21485862
DOI: 10.1166/jbn.2011.1260

Abstract

Mechanosensitive ion channel transduce physical stresses to cells by the response of electro-chemicals exchange. The purpose of this study was to improve understanding of ion channel inhibition process by SWCNTs. PatchDock and FireDock results suggest that the SWCNTs interact with the extracellular domain of the ion channels. SWCNTs can be considered as the new class of ion channel inhibitors.

MeSH terms

Animals
Computer Simulation
Extracellular Fluid / chemistry*
Humans
Ion Channel Gating*
Lipid Bilayers / chemistry*
Mechanotransduction, Cellular*
Models, Biological*
Models, Chemical*
Nanotubes, Carbon / chemistry*
Protein Structure, Tertiary

Substances

Lipid Bilayers
Nanotubes, Carbon