Cytotoxic and genotoxic impact of TiO2 nanoparticles on A549 cells

J Biomed Nanotechnol. 2011 Feb;7(1):22-3. doi: 10.1166/jbn.2011.1181.

Abstract

Titania nanoparticles are produced by tons, and included in commercial products, raising concerns about their potential impact on human health. This study relates their cytotoxic and genotoxic impact on a cell line representative of human lung, namely A549 alveolar epithelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cytotoxins / toxicity
  • Dose-Response Relationship, Drug
  • Humans
  • Lung Neoplasms / physiopathology*
  • Metal Nanoparticles / toxicity*
  • Mutagenicity Tests / methods*
  • Mutagens / toxicity
  • Titanium / toxicity
  • Toxicity Tests, Acute / methods*

Substances

  • Cytotoxins
  • Mutagens
  • titanium dioxide
  • Titanium