Abstract
A number of new 1-substituted-6H-pyrido[4,3-b]carbazole derivatives have been synthesized. Nine of the newly obtained compounds were subjected to preliminary in vitro cytostatic activity screening against murine leukemia (L1210), human lung cancer (A549) and human colon cancer (HT29) cell lines. One particular compound 6f exhibited over 20 times better activity against L1210 tumor cell line than the reference ellipticine.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Ellipticines / chemical synthesis*
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Ellipticines / pharmacology*
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HT29 Cells
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Ellipticines
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ellipticine