Melidianolic acid A and B, new antimalarial acyclic diterpenes from Aphanamixis grandifolia

Nat Prod Commun. 2011 Mar;6(3):323-6.

Abstract

Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / chemistry*
  • Antimalarials / pharmacology*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Drug Screening Assays, Antitumor
  • Humans
  • Meliaceae / chemistry*
  • Molecular Conformation
  • Optical Rotation
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plasmodium falciparum / drug effects

Substances

  • Antimalarials
  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Plant Extracts
  • melidianolic acid A
  • melidianolic acid B