Abstract
Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 microg/mL, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry*
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Antimalarials / pharmacology*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Diterpenes / chemistry*
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Drug Screening Assays, Antitumor
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Humans
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Meliaceae / chemistry*
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Molecular Conformation
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Optical Rotation
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plasmodium falciparum / drug effects
Substances
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Antimalarials
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Plant Extracts
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melidianolic acid A
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melidianolic acid B