How to assess the severity of atrophic gastritis

World J Gastroenterol. 2011 Apr 7;17(13):1690-3. doi: 10.3748/wjg.v17.i13.1690.

Abstract

Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.

Keywords: Atrophic gastritis; Endoscopy; Pepsinogen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood
  • Diagnostic Imaging
  • Endoscopy / methods
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Gastritis, Atrophic / blood
  • Gastritis, Atrophic / etiology*
  • Gastritis, Atrophic / pathology*
  • Gastritis, Atrophic / therapy
  • Helicobacter Infections / complications*
  • Helicobacter Infections / pathology
  • Helicobacter pylori / pathogenicity
  • Humans

Substances

  • Biomarkers